Thursday, April 18, 2013

Toshiba's Kirabook rocks a 2560 x 1440 display, arrives May 12th starting at $1,600

Toshiba announces premium KIRAbook, highresolution display and 256GB SSD starting at $1,599

Toshiba's been holding its own at the affordable end of the laptop and PC market for a while, but that doesn't mean it can't do classy. Perhaps that's why it's just announced KIRAbook, a 13-inch Ultrabook aimed squarely at the high end. All the usual top-tier treats are here, plus an impressive 2,560 x 1,440 (221 ppi) panel, making this the first Windows Ultrabook to offer such a high-resolution screen. There's also a pressed magnesium housing and touchscreen input (non-touch version also available). That tactile input option also comes with a 10-point Corning Concore sheet of glass between your digits and the Windows 8 operating system. That OS will be housed on a 256GB SSD, supported by 8GB of 1,600 MHz RAM and third-gen Intel Core processors. There is also 25GB of cloud storage if you need a little more. At launch, there will be three configurations starting at $1,599, rising to $1,999 if you want all the bells and whistles (i.e., Core i7 and that touchscreen). If this sounds like your thing, then you can pre-order in May 3rd, or walk into bricks and mortar stores on May 12th.

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Via: The Verge

Source: http://www.engadget.com/2013/04/17/toshiba-announces-premium-kirabook/

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Wednesday, April 17, 2013

A question about low muscle tone without flexing - Health, Fitness ...

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A question about low muscle tone without flexing
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PostPosted: Mon Apr 15, 2013 5:37 pm?? ?Post subject: A question about low muscle tone without flexing Reply with quote

I have muscles and you can only see them when i flex them. Are there any supplements or medication that can let my muscles become like a black man, their muscles are big without flexing while mine just look like fat and skinny.
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PostPosted: Mon Apr 15, 2013 6:53 pm?? ?Post subject: Reply with quote

I think low body-fat% and dark skin are the main factors that contribute to good muscle tone/definition, so using a tanning bed would probably help along with doing some cardio after lifting weights. Steroids obviously build muscle while burning body-fat at the same time which is why they give such good muscle tone/definition although I don't recommend them.
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PostPosted: Mon Apr 15, 2013 7:53 pm?? ?Post subject: Reply with quote

When a muscle becomes big enough it can be seen without flexing - black or white. I am (lovingly) called she - hulk by my boyfriend.. why? Because I have bigger muscles than him because I have had nerve damage in my spine that has caused my muscles to be in a constant micro flexing and over many years my muscles have built up. Having a tan may help.. but I also think it has to do with how your muscles are worked out. Look up weight training sites that can tell you how to exercise a muscle to give definition. Look into isometric exercise.. my boyfriend does those and he has muscles build pretty quick.. his arms look great!

But I believe part of being on the spectrum is low muscle tone. So you may have to work extra hard to build them up.

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Tuesday, April 16, 2013

PFT: Favre hopes for Green Bay return 'one day'

Howie RosemanAP

Eagles general manager Howie Roseman referred to this as a ?meat and potatoes? draft, making you wonder if he?s interested in the sizzle that drafting a quarterback would create.

While there?s a lot of speculation about the Eagles possiblity of drafting a player such as West Virginia?s Geno Smith, Roseman said this year?s draft was ?exciting,? because teams are ?built along the lines.?

According to Les Bowen of the Philadelphia Daily News, Roseman defended this year?s much-maligned quarterback class, saying that the strength of last year?s class makes it look weaker by comparison. But he called this crop of passers a ?normal? year, which may be generous.

While it?s possible to read that as a degree of endorsement for Smith, other answers point to support for Oregon defensive end Dion Jordan.

Roseman said the Eagles had to evaluate where a player would be in three years, and that fits with the developmental part of Jordan?s profile. Combined with his background with new Eagles coach Chip Kelly, and there?s a strong case to be made for Jordan at No. 4.

But Roseman also wanted folks to know he?s open for business, saying he had been asked if their pick was available.

?Even during the combine, you talk to people about their pick and what?s going on,? Roseman said. ?The serious conversation will pick up next week, when you?ve had a chance to sit back, look at your draft board, go through scenarios and figure out what you?re looking at and what you?re going to get.?

Especially if someone else is shopping for the steak.

Source: http://profootballtalk.nbcsports.com/2013/04/13/favre-wants-to-make-a-green-bay-appearance-one-day/related/

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Want to Know What Obamacare Will Really Be Like? Ask Someone in Massachusetts

Four years after Jaclyn Michalos, now 28, graduated from college, she felt a lump in one of her breasts. Living in Norwood, Massachusetts, Michalos had no insurance, figuring, she says, that she was healthy and any ailments that hit her could be treated with over-the-counter medicines from the drugstore. But once she felt the lump, Michalos saved up some money so she could have it checked. The doctor examined the lump and told her she was fine and that it wasn?t cancer.

A Quickie Guide to Obamacare: Four Big Changes You Need to Understand

?

?

But Michalos continued to worry. A year later, she applied for health insurance through Healthconnector, Massachusetts? health insurance exchange, opened in 2006 when the state passed health insurance reform requiring every adult in the state to be covered. Like the Affordable Care Act?(ACA), whose ?individual mandate? becomes effective in January 2014, Massachusetts offers assistance to people with low incomes. Michalos found out several surprising things: Comprehensive health insurance cost less than she expected; the HealthConnector exchange was able to easily help her find the best plan for her needs; and she did indeed have cancer. Now, a few years later, Michalos is cancer-free, and recently filmed a testimonial?to urge others in her state to sign up for coverage.

If Michalos? experience sounds a lot like what many of us expect from Obamacare, you?re right?there is a lot of overlap. Massachusetts? seven-year-old health reform program is a model for what?s about to happen across the nation, says Vicky Pulos, a staff attorney with the Massachusetts Health Reform Institute?(MHRI). ?Massachusetts was successful in reducing the number of the uninsured, which we did through several different programs,? says Pulos.

Why Everyone Under 26 Should Thank Obamacare

However, she adds that Massachusetts started out with a much lower rate of uninsured people than some other states, and a pretty high rate of employer insurance. ?And we chose to expand [Medicaid] coverage, while some states are choosing not to expand Medicaid for 2014, or saying they won?t, and that includes a lot of states with the largest number of uninsured in the country,? Pulos explains. ?So our success in reducing the number of uninsured may not be equaled across the country, at least not right away.?

Communication was also critical to Massachusetts? success, says Pulos. The commonwealth sent a postcard about the new insurance opportunities to all tax filers and gave out millions of dollars to community organizations to create education programs to explain the new ways people could get coverage. ?Both the carrot and the stick were certainly important,? says Pulos. ?The ?carrot? of coverage, and the ?stick? of the penalty for those who didn?t sign up.? As with Obamacare, most people who don?t have health insurance by a specified time will face a penalty.

10 Things Your Health Insurance Plan Will Soon Have to Cover

A May 2012 report from the Kaiser Family Foundation gave kudos to several specific parts of the Massachusetts health reform program:

? ?Expansion of coverage to nearly all state residents;

? ?Within a year of implementation the state experienced an unprecedented?drop in the number of uninsured and, despite the economic recession, it continues to retain the lowest rate of uninsured residents in the country; and

? ?More adults in Massachusetts than before reform now get preventive care and report a regular source of healthcare (having a medical ?home? is important for keeping people well, which in turn helps keeps healthcare costs down).

Bad News: Obamacare Is Going to Make the Doctor Shortage Worse

But Masschusetts isn?t an unqualified success, according to the Kaiser report. With more people covered, the demand for healthcare?particularly in underserved communities?has increased. That means people often have to wait a lot longer to see a doctor, and may need to be routed to physicians farther from where they live. The state is working to increase the number of providers by creating loan repayment opportunities for doctors and other providers in underserved areas. Many Americans can probably expect a similar side effect once Obamacare kicks in fully in January 2014.

Another issue the state is facing, according to the Kaiser report, is rising healthcare costs, because so many more people are seeking preventive care and treatment. The result is that Massachusetts has the highest individual market premiums in the country. Some experts are also predicting that premiums under the ACA will climb?or even skyrocket, though it remains to be seen if this will in fact happen.

"Cost containment" for the national health reform program?meaning efforts to keep both the cost of care and the cost of insurance premiumds down?has been built into the ACA, though MHRI?s Vicky Pulos says it will take a few years to see how well that works. One important effort is the Patient-Centered Outcomes Research Institute aimed at finding and sharing the most appropriate treatment choices for best outcomes as well as shoring up costs.

On the whole, outside of a crystal ball, Massachusetts is as good a bellwether as we currently have to imagine what life under Obamacare will look like?both the strengths and the weaknesses of the program. That's because no other state has taken such a bold step in an attempt to offer more of its citizens quality healthcare and reform out-of-control healthcare costs.

Do you think Massachusetts is a good example for the rest of the country to follow? What do you think the pros and cons of the ACA are?

Related Stories on TakePart:

? So You Think Obamacare is Radical? Take a Look at China

? Need Health Insurance? This is How You Get It Under Obamacare

? Affordable Care Act Won't End Disparities


Fran Kritz is a?freelance writer specializing in health and health?policy and lives in Silver?Spring, Maryland. Takepart.com

Source: http://news.yahoo.com/want-know-obamacare-really-ask-someone-massachusetts-212141174.html

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Monday, April 15, 2013

Rubio's Evolves on Immigration, Qualifies Support for Senate Bill ...

Shark Tank Media

Shark Tank Media

By JAVIER MANJARRES

Florida U.S. Senator Marco Rubio is now the official ?tip-of-the-spear? for the illegal immigration reform bill that is expected to come out of the U.S. Senate. Rubio appeared on NBC?s ?Meet the Press? with host David Gregory, where he got right into the weeds of the immigration reform debate.

?Rubio?s evolution on immigration reform continues, as the Senator is now using the term ?undocumented? instead of illegal to identify immigrants who have come here illegally.

?This bill once introduced as agreed to, I think, will show a broad base of enforcement measures unlike this country has ever seen. And what it does is create a way for us to address millions of people that are here undocumented , in a way that is compassionate, but also in a way that is responsible.-Senator Marco Rubio

?He then qualifies his support of the ?immigration bill, by stating that these illegal immigrants who are granted the chance to get on the pathway to citizenship, will not be awarded any special privileges, once they have applied.

It (the bill)will allow them to ultimately earn access to our legal immigration system, they will still have to apply, it doesn?t award them anything, but it does give them access to our legal immigration system to a process that will not encourage people to come here illegally in the future and though a process ?that isn?t unfair for people who have done it the right way.

?The status quo is horrible for America. The only people benefiting from the Status quo ?are in immigration today, are the people trafficking human beings across the border and the people hiring illegal labor for purposes.

?Amnesty is the forgiveness of something, and there will be consequences for having violated the law, and their will be reasonable consequences, but the type of consequences that ensure there is no incentive to do it this way again.

?Rubio reiterates his point that those who are already waiting in line to enter the US legally, that ?no one who has done it the wrong way will get it before you.?

?But then Rubio?s own words are used to put him in a bit of a bind. Host David Gregory asked Rubio what has changed in his immigration messaging since ?his 2010 Senatorial campaign. Gregory reminded Rubio that during one of the Senatorial debates, Rubio stated that to earn a pathway to citizenship, ?you have to leave this country if you are here illegally, go back home and then come back.?

?Rubio answered that during his campaign, he was against ?blanket amnesty? and this bill is not blanket amnesty, because ?you pay serious consequences for having violated the law.?

?The existing law does not prohibit someone who has violated the immigration laws from getting a green card it simply says you have to leave the US and wait ten? years. ?What we have done is created an alternative to that.

?Forces you to wait more than ten years, forces you to pay an application fee, forces you to pay a significant fine, forces you to not qualify for any federal benefits of any kind. Rubio then says that there would be ?no access to anything until there is a universal E-Verify system in place.?

?Gregory then asked Rubio what we here at the Shark Tank have also asked of Rubio, in respect to the almost certain possibility that this immigration bill will eventually morph into a bill that would force him to back off.

?Rubio said that if the bill changed for the worse and abandoned his principles, he ?would not support it, but doesn?t think that will happen.

?Again, when President Obama, who is in favor of amnesty for illegal immigrants, is the biggest cheerleader for this immigration bill, expect his agenda to be addressed.

Share and ?Like? the story below. ??Follow The Shark Tank on?Twitter?and?Facebook

// ]]>

Source: http://shark-tank.net/2013/04/14/rubios-evolves-on-immigration-qualifies-support-for-senate-bill/

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Joshua Tree park sites closed because of graffiti

JOSHUA TREE NATIONAL PARK, Calif. (AP) ? Acts of graffiti have become so pervasive at Joshua Tree National Park's most popular hiking spots that officials have had to close them to the public, and they blame the big bump in vandalism on social media.

Rangers said they've found graffiti spray painted on 17 sites, including the famous rock formations and historic Native American sites, at the Southern California park's Rattlesnake Canyon. They put historic Barker Dam off limits after vandals carved their names into the cement of the Old West landmark.

National Parks officials said the graffiti started with just a few markings, but quickly spread. They blame vandals who posted pictures of their handiwork on social media sites such as Facebook, which enticed others to the same spot and leave their own illicit marks.

"I've worked at six national parks, and this is the most extensive I've seen in 20 years," ranger Pat Pilcher told reporters this week during a tour of some of the damage.

For visitors who cherish the isolation of this harsh desert terrain about 140 miles east of downtown Los Angeles, the graffiti are an unwelcome reminder of city blight.

"You kind of feel like you're alone. In ancient times. There's nothing like this place," Butch Wood, 51, a visitor from North Aurora, Ill. Told the Los Angeles Times (http://lat.ms/12TCNU8). "You don't like to see the modern world intruding on history. It's a shame."

Pilcher said park service law enforcement officers are investigating the vandalism. If caught and convicted, vandals could face up to $5,000 in fines and six months in jail. He said the penalty could be stiffer for those convicted of defacing a historic Native American site.

Meanwhile, the San Bernardino County Sun reports (http://bit.ly/ZTjZN6 ) that officials are closing 308 acres of the canyon until April 30 while volunteers from the Urban School of San Francisco help scrub the graffiti off the giant granite boulders.

It wasn't clear how the park service will repair the damage at Barker Dam.

Source: http://news.yahoo.com/graffiti-force-closure-joshua-tree-park-sites-031203308.html

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Sunday, April 14, 2013

Clumps of Neurons Help Scientists Study Gut Disorders

neurospheres, glia, motility disorders Image: COURTESY OF DIPA NATARAJAN University College London AND RANIA KRONFLI Royal Hospital for Sick Children

These neurospheres?free-floating balls of glia (red), neurons (green) and stem cells?were cultivated in a lab from stem cells taken from the intestine or stomach of a mouse. Researchers use the neurospheres to test treatments for gut motility disorders, in which portions of the intestine, sometimes referred to as the second brain, lack sufficient nerve cells to function properly.

This article was originally published with the title Sphere of Influence.

Source: http://rss.sciam.com/click.phdo?i=880e0369f25f5818b499a983c81118d3

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Greek PM says deposits are safe, banks shielded: paper

ATHENS (Reuters) - Greek bank deposits are safe and the country's lenders are protected due to a recapitalization scheme which will be completed by the end of April, Prime Minister Antonis Samaras said on Saturday.

In an interview with Imerisia, Samaras ruled out a tax on deposits over 100,000 euros ($131,000) allaying fears of austerity-hit Greeks that their savings may be at risk after a raid on Cyprus depositors as part of the island's bailout.

"No, I'm categorical. There is no such issue. We have no reason to think about it," he said. "The Greek banking system is shielded due to the recapitalization."

Greek banks are consolidating to deal with a deep recession.

The banking sector was shaken this week by the unexpected suspension of National Bank's plans to integrate its newly acquired rival Eurobank after the lenders said they were unlikely to raise enough capital to stay private.

Samaras said the deal depends on the recapitalization. Under the terms of the plan, a minimum amount of new equity must be raised from the market for the banks to remain privately run.

"If the two banks raise the funds to recapitalize alone, then they will decide if they still want to merge. If they don't raise the demanded funds they will fall under the control of the Hellenic Financial Stability Fund which will decide if their merger is beneficial," he said.

Bank recapitalization is on the agenda of talks with the so-called troika of EU/IMF officials visiting Athens to monitor its fiscal progress. Other key issues include shrinking the country's spendthrift public sector and a real estate tax.

With the country's constitution protecting state workers from dismissal, Samaras said the government could reduce staff by scrapping job positions.

"There is no doubt we need a smaller but also better public sector," Samaras said. "The constitution doesn't ban the dismissal of state workers whose position has been scrapped."

(Reporting by Renee Maltezou; editing by Ron Askew)

Source: http://news.yahoo.com/greek-pm-says-deposits-safe-banks-shielded-paper-093914510--finance.html

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IAU: No, You Can't Name That Exoplanet

First off IAU has no authority to tell the public what they can and can't "officially" name anything neither do they have the right to redefine terms used by the public for thousands of years such as "planet".

Thousands of years ago, the Moon and the Sun were planets, and Uranus, Neptune, and Pluto were blurs below the level of visibility, even Tycho Brache's eyes. Pluto was a planet for less time than the Buddha was on the Calendar Of Saints (before the Christians actually talked to Buddhists, rather than hearing of him third or worse hand), so I can grimace and bear it.

Second how can any of us be certain these exoplanets are actually planets since I doubt we can really tell whether they have yet to clear their neighborhood?

Now THAT is a good one! Let them be hoisted on their own plutard!

Finally spending money to name/vote on planets is a fairly seedy activity leaving me with a low opinion of both organizations.

Actually, the IAU no more names these "planets" than does the IUPAC "name" fr

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/71GqkxNqUOg/story01.htm

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Saturday, April 13, 2013

The rise of Chinese venture capital (part 3 of 5) ? The Berkeley Blog

Steve Blank, lecturer, Haas School of Business | 4/12/13 | Steve Blank

I just spent a few weeks in Japan and China on a book tour for the?Japanese?andChinese?versions of the Startup Owners Manual.? In this series of 5 posts, I thought I?d share what I learned in China. All the usual caveats apply. I was only in China for a week so this a cursory view. Thanks to?Kai-Fu Lee?of Innovation Works, David Lin of Microsoft Accelerator, Frank Hawke of the?Stanford Center in Beijing,?and my publisher China Machine Press.

China speaking 2

The first post described how China built a science and technology infrastructure?to support advanced weapons systems development. The previous post described?how the Torch program built China?s innovation clusters. This post is about the rise of Chinese venture capital and how it helped build the countries entrepreneurial ecosystem.

The Rise of Chinese venture capital

China?s move away from a state system that solely depended on a command and control economy started in the 1990s.?The first wave of startups?began when R&D centers and universities began to provide the technology and seed capital for new startups that were spin-outs or spin-offs. This could be a group of individuals leaving a university or research center or an entire department leaving. For example, in the 1990?s 85% of the start-up funds of the new technology companies founded in Beijing came from the research center or university they left.

China Startup Funding

The second wave of technology investors were Chinese banks, who provided the majority of the later stage investments in the Torch Program. By 1991, 70% of the Torch funded startups were getting bank financing for expansion and later stages of the new ventures, with local governments acting as guarantors. Like the U.S. SBIR and STTR programs, the Torch Program?s funding for new ventures was limited to seed funding the front end. Being designated as a Torch Program startup gave banks comfort to provide loans to these ventures for technology commercialization.

Technology zones with Science and Technology Industrial Parks were the third source of support for new ventures. Inside the zones were Torch Technology Business Incubators?with startups licensed by the local governments.? These local governments financially supported the startups because, by locating in these zones, the new ventures were seen as contributing to local economic development. This helped the startups qualify for funding from banks and venture capital firms.

By the mid-1990s, Chinese leaders realized that the Torch program couldn?t be the source of all capital for startups. At the same time neither banks nor local governments had the cash to finance startups on the scale the country needed. The problem was that in China the government didn?t recognize venture capital firms as a legitimate organizational type. The founding of domestic VC firms began with the establishment of local government-financed venture capital firms (GVCFs), followed by university-backed VC firms (UVCFs). (The State Science and Technology Commission and the Ministry of Finance formed the China New Technology Venture Investment Corporation in 1986, but it was a government agency supporting national technology venture policy objectives, rather than a profit-oriented private enterprise. It went bankrupt in 1997.)

A few foreign VC firms like IDG Capital Partners entered China in the early 1990s. Gradually, from the mid-1990s, the perception of venture capital shifted from its being a type of government funding to being a commercial activity necessary to support the commercialization of new technology. But it wasn?t until 1998 that corporate-backed VC firms could be established, and that started a wave of VC funds backed by government, corporate and foreign capital.

A great summary diagram below from OECD?s?Report on China?s Innovation Policy?traces the evolution of China?s Innovation Ecosystem.

Evolution of China's Innovation Ecosystem

Investing in China today

Fast forward a decade, today the Private Equity and Venture Capital business is booming in China with over 1000 firms actively investing. Most of the early deals were done by offshore venture funds ? with their fund registered in countries outside China and using dollars. The latest trends are as?Renminbi?(?RMB?) funds (the Renminbi is the official currency in China.)

In the past, foreign funds who wanted to invest in China had to set up funds using dollars with complicated offshore structures with exits through offshore listings. The Renminbi funds have fewer restrictions on what industries the fund can invest in, less regulatory oversight and access to listing a portfolio company in China. There are two types of Renminbi funds: domestic funds and foreign-invested funds.? Domestic Renminbi funds are fully owned by Chinese investors, while foreign-invested Renminbi funds may be partially or fully owned by non-Chinese investors.? Both types of funds are organized under Chinese law and use Renminbi to invest in Chinese companies.

The other big change was the creation of ChiNext, China?s equivalent of NASDAQ stock exchange for start-ups, in 2009. The market was created to provide startups and their investors liquidity. Over 100 startups were listed on ChiNext the first year of its launch at sky-high valuations (average of 66 times earnings.) About 60% of the startups listed on ChiNext were backed by Renminbi funds, making the investors of these funds one of the main beneficiaries of the exchange.

The next posts,?Part 4 ?Zhongguancun in Beijing?? China?s Silicon Valley and?part 5, the Gold Rush and Fire Extinguishers,?describe the Beijing entrepreneurship ecosystem.

Lessons learned

  • China?s venture capital system has made a remarkable journey from the ?state owns everything? to the free market
  • It?s done it in a series of evolutionary stages, each new one learning from the last.

Source: http://blogs.berkeley.edu/2013/04/12/the-rise-of-chinese-venture-capital-part-3-of-5/

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Emma Watson Pole Dances In Exclusive 'The Bling Ring' Clip

Emma Watson, it's so good to see you go bad. MTV debuted an exclusive clip from her upcoming movie, "The Bling Ring," during Sneak Peek Week, and it shows Watson not playing her typical good-girl character. Ever wondered how Watson would work a stripper pole or react to seeing a closet full of expensive shoes [...]

Source: http://moviesblog.mtv.com/2013/04/13/emma-watson-pole-dance-bling-ring-clip/

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Secrets of bacterial slime revealed

Apr. 12, 2013 ? Newcastle University scientists have revealed the mechanism that causes a slime to form, making bacteria hard to shift and resistant to antibiotics.

When under threat, some bacteria can shield themselves in a slimy protective layer, known as a biofilm. It is made up of communities of bacteria held together to protect themselves from attack.

Biofilms cause dental plaque and sinusitis; in healthcare, biofilms can lead to life threatening and difficult to treat infections, particularly on medical implants such as catheters, heart valves, artificial hips and even breast implants. They also they coat the outside of ships and boats polluting the water.

Publishing in the Journal of Biological Chemistry, the team reveal how a molecular switch regulates biofilm formation. This new understanding could help identify a new target for antibiotics and prevent other biofilms from forming.

In order to thwart them from causing disease and biopollution, a Newcastle University team have been studying at the molecular level how bacteria form biofilms in the first instance.

They reveal how the master regulator of biofilm formation, a protein called SinR, acts in the model bacterium, Bacillus subtilis.

Richard Lewis, Professor of Structural Biology in the Institute for Cell and Molecular Biosciences who led the research said: "SinR is a bit like a rocker switch, a domestic light switch for instance. In the "down" position, when SinR is bound to DNA, the proteins required to make a biofilm are turned off and the bacteria are free to move. In the "up" position, SinR is no longer bound to DNA and instead interacts with other proteins, and the biofilms genes are turned on."

SinR is a DNA-binding protein that acts to inhibit the expression of proteins required for the synthesis of the molecular glue that holds the biofilm together. The ability of SinR to bind to DNA is carefully controlled by a network of interactions with three other proteins. By the application of X-ray crystallography, the team have determined precisely how SinR interacts with very specific feature of its DNA target.

By understanding how the proteins interact with each other, and with DNA, scientists can look to develop molecules that interfere with these essential processes as a means to stop biofilms from forming.

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The above story is reprinted from materials provided by Newcastle University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. A. Newman, C. Rodrigues, R. J. Lewis. Molecular Basis of the Activity of SinR Protein, the Master Regulator of Biofilm Formation in Bacillus subtilis. Journal of Biological Chemistry, 2013; 288 (15): 10766 DOI: 10.1074/jbc.M113.455592

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/x0aTqNmybYM/130412132413.htm

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Lazaro Arbos on American Idol Elimination: I Sort of Won!

Source: http://www.thehollywoodgossip.com/2013/04/lazaro-arbos-on-american-idol-elimination-i-sort-of-won/

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Facebook's Zuckerberg launches political group

(AP) ? Teaming up with other Silicon Valley leaders, Facebook CEO Mark Zuckerberg has formally launched a political group aimed at revamping immigration policy, boosting education and encouraging investment in scientific research.

Zuckerberg announced the formation of Fwd.us (pronounced "forward us") in an op-ed article in The Washington Post late Wednesday. In it, he said the U.S. needs a new approach to these issues if it is to get ahead economically. This, he wrote, includes offering talented, skilled immigrants a path to citizenship.

"We have a strange immigration policy for a nation of immigrants," Zuckerberg wrote. "And it's a policy unfit for today's world."

The move comes as a bipartisan Senate group is expected to roll out on a comprehensive immigration bill in the coming days. Zuckerberg's goal echoes the proposed legislation. He said he wants "comprehensive immigration reform that begins with effective border security, allows a path to citizenship and lets us attract the most talented and hardest-working people, no matter where they were born."

Zuckerberg also calls for higher standards and accountability in schools and increased focus on learning about science, technology, engineering and math. Today's knowledge and ideas-based economy, the 28-year-old Harvard dropout wrote, is very different from the economy of the 20th century that was based on natural resources, industrial machines and labor.

Fwd.us, he said, was created to "to build the knowledge economy the United States needs to ensure more jobs, innovation and investment."

Also backing the group are tech leaders such as LinkedIn Corp. CEO Reid Hoffman, venture capitalists John Doerr and Jim Breyer, as well as Ruchi Sanghvi of Dropbox, who was Facebook Inc.'s first female engineer. Joe Green, founder of Causes.com, a social network for community organizing, serves as the group's president and founder.

Major contributors include Google Inc. chairman Eric Schmidt, Netflix Inc. CEO Reed Hastings, Yahoo Inc. CEO Marissa Mayer, SpaceX and Tesla Motors CEO Elon Musk, Zynga Inc. CEO Mark Pincus and former Groupon Inc. CEO Andrew Mason.

The formation of Zuckerberg's group was reported by The Associated Press and other outlets last month.

__

Associated Press writer Erica Werner contributed to this story from Washington.

___

Online:

Zuckerberg's op-ed: http://wapo.st/16SYUXs

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-11-Zuckerberg-Political%20Group/id-c86d37db3e304f368703fa134a4edb71

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Friday, April 12, 2013

Annals and ACP announce recipients of Junior Investigator Recognition Awards

Annals and ACP announce recipients of Junior Investigator Recognition Awards [ Back to EurekAlert! ] Public release date: 11-Apr-2013
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Contact: Angela Collom
acollom@acponline.org
215-351-2653
American College of Physicians

April 10, 2013 -- Annals of Internal Medicine and the American College of Physicians (ACP) will honor Adrienne Allen, MD, MPH and Matthew Spitzer, MD with the Junior Investigator Recognition Awards at Internal Medicine 2013, the annual scientific meeting of the American College of Physicians. Both honorees will be on site in San Francisco on Saturday, April 13, to present their winning research.

Now in its third year, Annals' Junior Investigator Recognition Awards are presented annually to two junior physicians. Annals and ACP award the most outstanding article by a first author who is in an internal medicine residency program or a general medicine or internal medicine subspecialty fellowship program. An award also is given for the most outstanding article with a first author who is within three years of completing his or her training in internal medicine or one of its subspecialties.

Dr. Allen, Associate Medical Director of Quality, Safety, and Risk at North Shore Physicians Group at North Shore Physicians Group in Boston, is being recognized for an article she authored while in training. "Pharmacy Dispensing of Electronically Discontinued Medications" was published in the November 20, 2012 issue of Annals of Internal Medicine. Her research highlighted an important patient safety concern. More than 85,000 medications are discontinued each year by physicians. While physicians may share this information with their patients, it is not always shared with the pharmacists. The researchers found that 1.5 percent all off discontinued medications were refilled by the pharmacy and that 12 percent of those refilled medications had the potential to cause some degree of harm to the patients.

Dr. Spitzer, Endocrinology Fellow at Boston Medical Center, is being recognized for an article he authored within three years of completing his training. "Effects of Testosterone Replacement on Response to Sildenafil Citrate in Men with Erectile Dysfunction: A Randomized Controlled Trial" was also published in the November 20, 2012 issue of Annals of Internal Medicine. The research showed that men with erectile dysfunction and low testosterone levels who received a replacement dose of testosterone with sildenafil did not have greater improvement in erectile function than men who received sildenafil plus placebo.

Winners are selected based on the article's novelty, methodological rigor, clarity of presentation, and potential to influence practice, policy, or future research. Judges include Annals' editors and representatives from Annals' Editorial Board and ACP's Education and Publication Committee.

###

About Annals of Internal Medicine

Annals of Internal Medicine is one of the five most widely cited peer-reviewed medical journals in the world, with a current impact factor of 16.7. The journal has been published for 86 years. It accepts only 7 percent of the original research studies submitted for publication. Follow Annals on Twitter and Facebook.

About the American College of Physicians

The American College of Physicians is the largest medical specialty organization and the second-largest physician group in the United States. ACP members include 133,000 internal medicine physicians (internists), related subspecialists, and medical students. Internal medicine physicians are specialists who apply scientific knowledge and clinical expertise to the diagnosis, treatment, and compassionate care of adults across the spectrum from health to complex illness. Follow ACP on Twitter and Facebook.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Annals and ACP announce recipients of Junior Investigator Recognition Awards [ Back to EurekAlert! ] Public release date: 11-Apr-2013
[ | E-mail | Share Share ]

Contact: Angela Collom
acollom@acponline.org
215-351-2653
American College of Physicians

April 10, 2013 -- Annals of Internal Medicine and the American College of Physicians (ACP) will honor Adrienne Allen, MD, MPH and Matthew Spitzer, MD with the Junior Investigator Recognition Awards at Internal Medicine 2013, the annual scientific meeting of the American College of Physicians. Both honorees will be on site in San Francisco on Saturday, April 13, to present their winning research.

Now in its third year, Annals' Junior Investigator Recognition Awards are presented annually to two junior physicians. Annals and ACP award the most outstanding article by a first author who is in an internal medicine residency program or a general medicine or internal medicine subspecialty fellowship program. An award also is given for the most outstanding article with a first author who is within three years of completing his or her training in internal medicine or one of its subspecialties.

Dr. Allen, Associate Medical Director of Quality, Safety, and Risk at North Shore Physicians Group at North Shore Physicians Group in Boston, is being recognized for an article she authored while in training. "Pharmacy Dispensing of Electronically Discontinued Medications" was published in the November 20, 2012 issue of Annals of Internal Medicine. Her research highlighted an important patient safety concern. More than 85,000 medications are discontinued each year by physicians. While physicians may share this information with their patients, it is not always shared with the pharmacists. The researchers found that 1.5 percent all off discontinued medications were refilled by the pharmacy and that 12 percent of those refilled medications had the potential to cause some degree of harm to the patients.

Dr. Spitzer, Endocrinology Fellow at Boston Medical Center, is being recognized for an article he authored within three years of completing his training. "Effects of Testosterone Replacement on Response to Sildenafil Citrate in Men with Erectile Dysfunction: A Randomized Controlled Trial" was also published in the November 20, 2012 issue of Annals of Internal Medicine. The research showed that men with erectile dysfunction and low testosterone levels who received a replacement dose of testosterone with sildenafil did not have greater improvement in erectile function than men who received sildenafil plus placebo.

Winners are selected based on the article's novelty, methodological rigor, clarity of presentation, and potential to influence practice, policy, or future research. Judges include Annals' editors and representatives from Annals' Editorial Board and ACP's Education and Publication Committee.

###

About Annals of Internal Medicine

Annals of Internal Medicine is one of the five most widely cited peer-reviewed medical journals in the world, with a current impact factor of 16.7. The journal has been published for 86 years. It accepts only 7 percent of the original research studies submitted for publication. Follow Annals on Twitter and Facebook.

About the American College of Physicians

The American College of Physicians is the largest medical specialty organization and the second-largest physician group in the United States. ACP members include 133,000 internal medicine physicians (internists), related subspecialists, and medical students. Internal medicine physicians are specialists who apply scientific knowledge and clinical expertise to the diagnosis, treatment, and compassionate care of adults across the spectrum from health to complex illness. Follow ACP on Twitter and Facebook.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/acop-aaa041113.php

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Pentagon: NKorea could launch nuclear missile

National Intelligence Director James Clapper testifies on Capitol Hill in Washington, Thursday, April 11, 2013, before the House Intelligence Committee hearing on worldwide threats. (AP Photo/Manuel Balce Ceneta)

National Intelligence Director James Clapper testifies on Capitol Hill in Washington, Thursday, April 11, 2013, before the House Intelligence Committee hearing on worldwide threats. (AP Photo/Manuel Balce Ceneta)

National Intelligence Director James Clapper, left, and CIA Director John Brennan testify on Capitol Hill in Washington, Thursday, April 11, 2013, before the House Intelligence Committee hearing on worldwide threats. (AP Photo/Manuel Balce Ceneta)

Department of Defense's Defense Intelligence Agency Director, Lt. Gen. Michael Flynn testifies on Capitol Hill in Washington, Thursday, April 11, 2013, before the House Intelligence Committee hearing on worldwide threats. (AP Photo/Manuel Balce Ceneta)

FBI Director Robert Mueller listens on Capitol Hill in Washington, Thursday, April 11, 2013, during the House Intelligence Committee hearing on worldwide threats. Mueller was among intelligence agency heads who testified before the committee. (AP Photo/Manuel Balce Ceneta)

CIA Director John Brennan testifies on Capitol Hill in Washington, Thursday, April 11, 2013, before the House Intelligence Committee hearing on worldwide threats. (AP Photo/Manuel Balce Ceneta)

(AP) ? A U.S. intelligence report concludes that North Korea has advanced its nuclear knowhow to the point that it could arm a ballistic missile with a nuclear warhead, a jarring revelation in the midst of bellicose threats from the unpredictable communist regime.

President Barack Obama urged calm, calling on Pyongyang to end its saber-rattling while sternly warning that he would "take all necessary steps" to protect American citizens.

The new American intelligence analysis, disclosed Thursday at a hearing on Capitol Hill, says the Pentagon's intelligence wing has "moderate confidence" that North Korea has nuclear weapons capable of delivery by ballistic missiles but that the weapon was unreliable.

Rep. Doug Lamborn, R-Colo., read aloud what he said was an unclassified paragraph from a secret Defense Intelligence Agency report that was supplied to some members of Congress. The reading seemed to take Gen. Martin Dempsey, chairman of the Joint Chiefs of Staff, by surprise, who said he hadn't seen the report and declined to answer questions about it.

In a statement late Thursday, Pentagon press secretary George Little said: "While I cannot speak to all the details of a report that is classified in its entirety, it would be inaccurate to suggest that the North Korean regime has fully tested, developed or demonstrated the kinds of nuclear capabilities referenced" in Lamborn's remarks.

'"The United States continues to closely monitor the North Korean nuclear program and calls upon North Korea to honor its international obligations," Little added.

The DIA conclusion was confirmed by a senior congressional aide who spoke on condition of anonymity because the Pentagon had not officially released the contents. The aide said the report was produced in March.

Since the beginning of March, the Navy has moved two missile defense ships closer to the coast of the Korean peninsula, in part to protect against a potential missile launch aimed at Guam, a U.S. territory in the Pacific. The Pentagon also has announced it will place a more advanced land-based missile defense on Guam, and Hagel said in March that he approved installing 14 additional missile interceptors in Alaska to bolster a portion of the missile defense network that is designed to protect all of U.S. territory.

On Thursday, the Pentagon said it had moved a sea-based X-band radar ? designed to track warheads in flight ? into position in the Pacific.

Notably absent from that unclassified segment of the report was any reference to what the DIA believes is the range of a missile North Korea could arm with a nuclear warhead. Much of its missile arsenal is capable of reaching South Korea and Japan, but Kim has threatened to attack the United States as well.

At the House Armed Services Committee hearing in which he revealed the DIA assessment, Lamborn asked Dempsey, whether he agreed with it. Dempsey said he had not seen the report.

"You said it's not publicly released, so I choose not to comment on it," Dempsey said.

But David Wright, a nuclear weapons expert at the Union of Concerned Scientists, said the DIA assessment probably does not change the views of those who closely follow developments in North Korea's pursuit of a nuclear weapon.

"People are starting to believe North Korea very likely has the capability to build a nuclear weapon small enough to put on some of their shorter-range missiles," Wright said. "Once you start talking about warheads small enough and technically capable to be on a long-range missile, I think it's much more an open question."

The DIA assessment is not out of line with comments Dempsey made Wednesday when he was asked at a Pentagon news conference whether North Korea was capable of pairing a nuclear warhead to a ballistic missile that could reach Japan or beyond.

In response, Dempsey said the extent of North Korean progress on designing a nuclear weapon small enough to operate as a missile warhead was a classified matter. But he did not rule out that the North has achieved the capability revealed in the DIA report.

"They have conducted two nuclear tests," Dempsey told a Pentagon news conference. "They have conducted several successful ballistic missile launches. And in the absence of concrete evidence to the contrary, we have to assume the worst case, and that's why we're postured as we are today." He was referring to recent moves by the U.S. to increase its missile defense capabilities in the Pacific.

At the same House hearing where Lamborn revealed the DIA conclusion, Defense Secretary Chuck Hagel was asked a different version of the same question: Does North Korea have the capability to strike U.S. territory with a nuclear weapon? Hagel said the answer is no.

"Now does that mean that they won't have it or they can't have it or they're not working on it?" Hagel added. "No. That's why this is a very dangerous situation."

"Now is the time for North Korea to end the belligerent approach they have taken and to try to lower temperatures," Obama said in his first public comments since Pyongyang threatened the United States and its allies in East Asia with nuclear attack.

Obama, speaking from the Oval Office, said he preferred to see the tensions on the peninsula resolved through diplomatic means, but added that "the United States will take all necessary steps to protect its people."

The North on Thursday delivered a fresh round of war rhetoric with claims it has "powerful striking means" on standby, the latest in a torrent of warlike threats seen by outsiders as an effort to scare and pressure South Korea and the U.S. into changing their North Korea policies.

Lamborn is a member of the Strategic Forces subcommittee of the Armed Services panel, which oversees ballistic missiles. A former state legislator who was elected to the House in 2006, was a member of the Tea Party caucus and belongs to the Republican Study Committee, the caucus of House conservatives

At a separate hearing Thursday, U.S. officials offered their assessment of the North Korean leader, who is a grandson of the country's founder, Kim Il Sung.

Director of National Intelligence James Clapper told the House Intelligence Committee that he thinks Kim, who took control after his father, Kim Jong Il, died in 2011, is trying to show the U.S., the world and his own people that he is "firmly in control in North Korea," while attempting to maneuver the international community into concessions in future negotiations.

"I don't think ... he has much of an endgame other than to somehow elicit recognition" and to turn the nuclear threat into "negotiation and to accommodation and presumably for aid," Clapper said.

Clapper said that the intelligence community believes the North would use nuclear weapons only to preserve the Kim regime but that analysts do not know how the regime defines that.

Secretary of State John Kerry was headed Thursday to East Asia, where he planned talks with officials in Seoul, Beijing and Tokyo about North Korea.

___

Associated Press writers Kimberly Dozier, Sagar Meghani and Donna Cassata contributed to this report.

___

Follow Robert Burns at http://www.twitter.com/robertburnsAP and Julie Pace at http://www.twitter.com/jpaceDC

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-11-US-Intelligence-Threats-North-Korea/id-498e4af78f6d4f55a86e1accaf50df85

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Farrah Abraham Porn: Still For Sale, Probably Not Worth $2M, Definitely Not For Personal Use

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